Toxicology International (Formerly Indian Journal of Toxicology)

Mukesh Mangal ¹, Suresh Kumar Sharma ¹

Affiliations
1 Department of Veterinary Pharmacology and Toxicology, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, Punjab, IN

Abstract

Aim: Cefquinome, a fourth generation of cephalosporins have been developed for use in animals. Similar to other species, it may also have some adverse reactions in buffalo calves at therapeutic dosage. In the present study, effect of repeated administration of cefquinome on biochemical and hematological parameters was studied in buffalo calves. Materials and Methods: Animals were divided into two groups having three animals in each group. Group 1 was kept as control and animals of Group 2 were given cefquinome at dose rate of 2 mg.kg⁻¹ body weight by intramuscular route for continuously 7 days. Blood samples were collected daily and 3 days post treatment. Results: The values of aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma‑glutamyl transpeptidase (GGTP), and alkaline phosphatase (ALKP) in control animals were in the range of 127.7–148.3 IU/L,49.0–55.6 IU/L, 14.0–17.3 IU/L, and 111.0–134.3 IU/L, respectively. The repeated administration of cefquinome did not influence the plasma activities of AST, ALT, GGTP, and ALKP in treated animals. The level of blood urea nitrogen (BUN) and creatinine before treatment was 14.3 ± 0.88 mg/dl and1.70 ± 0.04 mg/dl, which significantly increased on 3^rd day (21.0 ± 1.53 mg/dl) and 2^nd day (2.33 ± 0.07 mg/dl), respectively. Among hematological parameters, there was significant variation in levels of hemoglobin (Hb), total erythrocyte count (TEC), erythrocyte sedimentation rate (ESR), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin concentration (MCHC) in treated animals. No abnormal clinical symptoms were observed in any animal. Conclusion: The results revealed that clinically, the therapy of cefquinome may be continued up to 7 days.

Keywords

Biochemical Effects, Buffalo Calves, Cefquinome, Hematological Effects.

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